Insider Trading activities at Opko Health, Inc. (OPK) , Part 8

Insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Opko Health, Inc. (OPK) since 2006 are shown in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Opko Health, Inc.. (See page 1 of this report.) Table 2 shows the detailed insider transactions. This company's CIK number is 944809.

Total stock buying since 2006: $446,749,594.
Total stock sales since 2006: $4,562,093.
Total stock option exercises since 2006: $44,859,310.

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Table 1. Yearly summary of insider stock purchases, sales, and option exercises at *Opko Health, Inc.* (*OPK*).
	Insider Buying		Insider Sales		Option Exercises
Year	Shares	Value	Shares	Value	Shares	Value
2025	1,464,971	$2,268,356	0	$0	0	$0
2024	11,060,977	$11,232,662	0	$0	0	$0
2023	2,620,245	$4,028,551	0	$0	0	$0
2022	6,065,071	$15,298,160	0	$0	0	$0
2021	1,675,010	$6,733,537	0	$0	60,000	$152,100
2020	6,378,018	$12,211,808	0	$0	0	$0
2019	10,968,536	$20,157,698	0	$0	24,877	$16,418
2018	4,280,235	$15,828,016	0	$0	75,000	$257,250
2017	4,309,300	$29,248,220	112,975	$911,708	781,707	$2,316,267
2016	2,040,400	$18,843,589	37,500	$368,775	280,000	$313,400
2015	3,413,575	$38,939,224	41,488	$606,305	29,803,340	$26,767,986
2014	6,735,138	$56,715,211	226,030	$1,897,224	2,387,169	$5,701,640
2013	5,730,601	$42,219,434	50,000	$335,850	6,951,413	$8,990,168
2012	11,955,478	$54,117,205	0	$0	100,000	$203,700
2011	8,737,635	$32,428,441	50,000	$169,850	50,000	$28,000
2010	1,078,171	$2,505,315	0	$0	0	$0
2009	6,754,517	$6,502,506	0	$0	50,403	$43,094
2008	15,658,469	$25,674,488	100,000	$175,131	395,798	$69,287
2007	20,931,416	$51,795,693	29,500	$97,250	0	$0
2006	2,000	$1,480	0	$0	0	$0

Table 3. Detailed insider trading at *Opko Health, Inc.* (*OPK*) , Part 8
Trade Date	Insider Name	Trade Type	Shares	Price ($)	Value ($)
2013-01-04	Frost Gamma Investments Trust (10% Owner)	Buy	40,000	5.17	206,600
2013-01-03	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	5.03	125,750
2013-01-02	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	4.98	149,310
2012-12-31	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	4.71	471,500
2012-12-28	Frost Gamma Investments Trust (10% Owner)	Buy	55,000	4.75	261,415
2012-12-27	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	4.70	117,524
2012-12-26	Frost Gamma Investments Trust (10% Owner)	Buy	85,000	4.68	397,970
2012-12-24	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	4.63	138,960
2012-12-21	Frost Gamma Investments Trust (10% Owner)	Buy	80,000	4.66	372,879
2012-12-20	Frost Gamma Investments Trust (10% Owner)	Buy	62,500	4.73	295,625
2012-12-19	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	4.77	95,340
2012-12-18	Frost Gamma Investments Trust (10% Owner)	Buy	35,000	4.67	163,555
2012-12-17	Frost Gamma Investments Trust (10% Owner)	Buy	40,000	4.61	184,360
2012-12-14	Frost Gamma Investments Trust (10% Owner)	Buy	40,000	4.58	183,280
2012-12-14	Pfenniger Richard C Jr (Director)	Option Ex	100,000	2.04	203,700
2012-12-13	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	4.54	136,200
2012-12-12	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	4.54	136,110
2012-12-11	Frost Gamma Investments Trust (10% Owner)	Buy	40,000	4.50	179,800
2012-12-10	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	4.39	131,850
2012-12-07	Frost Gamma Investments Trust (10% Owner)	Buy	75,000	4.36	326,850
2012-12-06	Frost Gamma Investments Trust (10% Owner)	Buy	35,000	4.36	152,635
2012-12-05	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	4.38	131,430
2012-12-04	Frost Gamma Investments Trust (10% Owner)	Buy	32,500	4.38	142,415
2012-12-03	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	4.40	109,925
2012-11-30	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	4.45	88,900
2012-11-29	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	4.46	133,650
2012-11-28	Frost Gamma Investments Trust (10% Owner)	Buy	85,000	4.41	374,510
2012-11-27	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	4.43	44,320
2012-11-26	Frost Gamma Investments Trust (10% Owner)	Buy	65,000	4.43	287,950
2012-11-23	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	4.46	111,525
2012-11-21	Frost Gamma Investments Trust (10% Owner)	Buy	45,000	4.43	199,395
2012-11-20	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	4.46	33,412
2012-11-19	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	4.41	44,100
2012-11-16	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	4.39	109,749
2012-11-15	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	4.43	110,674
2012-11-14	Frost Gamma Investments Trust (10% Owner)	Buy	62,500	4.42	276,375
2012-11-13	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	4.49	67,365
2012-11-12	Frost Gamma Investments Trust (10% Owner)	Buy	77,500	4.43	343,325
2012-11-09	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	4.52	113,025
2012-11-08	Frost Gamma Investments Trust (10% Owner)	Buy	35,000	4.57	159,810
2012-11-07	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	4.33	216,750
2012-11-06	Frost Gamma Investments Trust (10% Owner)	Buy	75,000	4.24	317,700
2012-11-05	Frost Gamma Investments Trust (10% Owner)	Buy	65,000	4.25	276,250
2012-11-02	Frost Gamma Investments Trust (10% Owner)	Buy	80,000	4.26	340,880
2012-11-01	Frost Gamma Investments Trust (10% Owner)	Buy	75,000	4.30	322,200
2012-10-31	Frost Gamma Investments Trust (10% Owner)	Buy	75,000	4.28	320,775
2012-10-26	Frost Gamma Investments Trust (10% Owner)	Buy	75,000	4.34	325,575
2012-10-25	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	4.43	110,750
2012-10-24	Frost Gamma Investments Trust (10% Owner)	Buy	42,500	4.50	191,292
2012-10-23	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	4.46	111,625
2012-10-22	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	4.45	111,300
2012-10-19	Frost Gamma Investments Trust (10% Owner)	Buy	190,000	4.53	859,750
2012-10-11	Frost Gamma Investments Trust (10% Owner)	Buy	105,000	4.30	452,024
2012-10-10	Frost Gamma Investments Trust (10% Owner)	Buy	55,000	4.30	236,280
2012-10-09	Frost Gamma Investments Trust (10% Owner)	Buy	95,900	4.34	416,014
2012-10-09	Hsiao Jane Ph D (Vice Chairman & CTO)	Buy	10,000	4.33	43,320
2012-10-08	Frost Gamma Investments Trust (10% Owner)	Buy	137,500	4.43	609,125
2012-10-05	Frost Gamma Investments Trust (10% Owner)	Buy	60,000	4.50	269,820
2012-10-04	Frost Gamma Investments Trust (10% Owner)	Buy	77,500	4.41	341,465
2012-10-03	Frost Gamma Investments Trust (10% Owner)	Buy	65,000	4.34	282,425
2012-10-02	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	4.18	418,300
2012-10-01	Frost Gamma Investments Trust (10% Owner)	Buy	212,500	4.16	883,149
2012-09-28	Frost Gamma Investments Trust (10% Owner)	Buy	47,500	4.20	199,310
2012-09-27	Frost Gamma Investments Trust (10% Owner)	Buy	62,500	4.17	260,749
2012-09-26	Frost Gamma Investments Trust (10% Owner)	Buy	75,000	4.13	309,600
2012-09-25	Frost Gamma Investments Trust (10% Owner)	Buy	40,000	4.16	166,360
2012-09-24	Frost Gamma Investments Trust (10% Owner)	Buy	45,000	4.16	187,065
2012-09-21	Frost Gamma Investments Trust (10% Owner)	Buy	150,000	4.23	634,050
2012-09-20	Frost Gamma Investments Trust (10% Owner)	Buy	110,000	4.31	473,880
2012-09-19	Frost Gamma Investments Trust (10% Owner)	Buy	45,000	4.41	198,450
2012-09-18	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	4.43	110,750
2012-09-17	Frost Gamma Investments Trust (10% Owner)	Buy	40,000	4.41	176,280
2012-09-14	Frost Gamma Investments Trust (10% Owner)	Buy	55,000	4.47	245,740
2012-09-13	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	4.43	132,930
2012-09-12	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	4.38	131,250
2012-09-11	Frost Gamma Investments Trust (10% Owner)	Buy	60,000	4.38	262,620
2012-09-10	Frost Gamma Investments Trust (10% Owner)	Buy	90,000	4.40	395,640
2012-09-07	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	4.47	223,550
2012-08-31	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	4.47	89,320
2012-08-30	Frost Gamma Investments Trust (10% Owner)	Buy	22,500	4.45	100,035
2012-08-29	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	4.48	89,540
2012-08-28	Frost Gamma Investments Trust (10% Owner)	Buy	45,000	4.46	200,745
2012-08-27	Frost Gamma Investments Trust (10% Owner)	Buy	42,500	4.49	190,740
2012-08-24	Frost Gamma Investments Trust (10% Owner)	Buy	47,500	4.49	213,037
2012-08-23	Frost Gamma Investments Trust (10% Owner)	Buy	32,500	4.44	144,300
2012-08-22	Frost Gamma Investments Trust (10% Owner)	Buy	35,000	4.38	153,440
2012-08-21	Frost Gamma Investments Trust (10% Owner)	Buy	80,000	4.33	346,079
2012-08-20	Frost Gamma Investments Trust (10% Owner)	Buy	65,000	4.31	280,345
2012-08-17	Frost Gamma Investments Trust (10% Owner)	Buy	75,000	4.28	321,300
2012-08-16	Frost Gamma Investments Trust (10% Owner)	Buy	60,000	4.23	253,979
2012-08-15	Frost Gamma Investments Trust (10% Owner)	Buy	40,000	4.19	167,600
2012-08-14	Frost Gamma Investments Trust (10% Owner)	Buy	45,000	4.19	188,595
2012-08-13	Frost Gamma Investments Trust (10% Owner)	Buy	60,000	4.22	253,260
2012-08-10	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	4.24	423,600
2012-08-09	Frost Gamma Investments Trust (10% Owner)	Buy	70,000	4.26	297,920
2012-08-08	Frost Gamma Investments Trust (10% Owner)	Buy	47,500	4.25	201,922
2012-08-07	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	4.28	214,000
2012-08-06	Frost Gamma Investments Trust (10% Owner)	Buy	115,000	4.28	492,430
2012-08-03	Frost Gamma Investments Trust (10% Owner)	Buy	60,000	4.27	256,260
2012-08-02	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	4.13	412,600
2012-08-01	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	4.12	823,199
2012-07-31	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	4.24	424,099
2012-07-30	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	4.32	431,799
2012-07-30	Hsiao Jane Ph D (Vice Chairman & CTO)	Buy	30,000	4.35	130,499
2012-07-27	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	4.34	433,600
2012-07-27	Hsiao Jane Ph D (Vice Chairman & CTO)	Buy	20,000	4.30	86,000
2012-07-26	Frost Gamma Investments Trust (10% Owner)	Buy	185,000	4.34	803,085
2012-07-25	Frost Gamma Investments Trust (10% Owner)	Buy	65,000	4.41	286,390
2012-07-23	Frost Gamma Investments Trust (10% Owner)	Buy	40,000	4.47	179,000
2012-07-20	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	4.50	135,000
2012-07-19	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	4.61	115,250
2012-07-18	Frost Gamma Investments Trust (10% Owner)	Buy	32,500	4.64	150,962
2012-07-17	Frost Gamma Investments Trust (10% Owner)	Buy	85,000	4.58	389,725
2012-07-13	Frost Gamma Investments Trust (10% Owner)	Buy	45,000	4.61	207,585
2012-07-12	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	4.59	137,850
2012-07-11	Frost Gamma Investments Trust (10% Owner)	Buy	92,500	4.55	421,059
2012-07-10	Frost Gamma Investments Trust (10% Owner)	Buy	90,000	4.61	415,080
2012-07-09	Frost Gamma Investments Trust (10% Owner)	Buy	45,000	4.65	209,250
2012-07-06	Frost Gamma Investments Trust (10% Owner)	Buy	90,000	4.70	423,089
2012-07-05	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	4.76	237,800
2012-07-03	Frost Gamma Investments Trust (10% Owner)	Buy	45,000	4.71	211,860
2012-07-02	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	4.64	232,100
2012-06-29	Frost Gamma Investments Trust (10% Owner)	Buy	42,500	4.59	194,947
2012-06-28	Frost Gamma Investments Trust (10% Owner)	Buy	77,500	4.56	353,632
2012-06-27	Frost Gamma Investments Trust (10% Owner)	Buy	12,500	4.62	57,762
2012-06-26	Frost Gamma Investments Trust (10% Owner)	Buy	17,500	4.62	80,797
2012-06-25	Frost Gamma Investments Trust (10% Owner)	Buy	12,500	4.62	57,750
2012-06-22	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	4.57	137,100
2012-06-19	Frost Gamma Investments Trust (10% Owner)	Buy	77,500	4.47	346,657
2012-06-18	Frost Gamma Investments Trust (10% Owner)	Buy	65,000	4.50	292,630
2012-06-15	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	4.60	920,800
2012-06-14	Frost Gamma Investments Trust (10% Owner)	Buy	85,000	4.69	398,480
2012-06-13	Frost Gamma Investments Trust (10% Owner)	Buy	35,000	4.79	167,615
2012-06-12	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	4.75	23,760
2012-06-11	Frost Gamma Investments Trust (10% Owner)	Buy	42,500	4.77	202,555
2012-06-08	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	4.71	117,850
2012-06-07	Frost Gamma Investments Trust (10% Owner)	Buy	45,000	4.60	207,090
2012-06-05	Frost Gamma Investments Trust (10% Owner)	Buy	27,500	4.50	123,640
2012-06-04	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	4.49	89,740
2012-06-01	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	4.49	134,700
2012-05-31	Frost Gamma Investments Trust (10% Owner)	Buy	110,000	4.61	506,990
2012-05-30	Frost Gamma Investments Trust (10% Owner)	Buy	35,000	4.66	162,925
2012-05-25	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	4.81	72,150
2012-05-24	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	4.75	118,625
2012-05-23	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	4.59	91,800
2012-05-22	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	4.61	92,200
2012-05-21	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	4.54	90,700
2012-05-18	Frost Gamma Investments Trust (10% Owner)	Buy	40,000	4.50	179,800
2012-05-17	Frost Gamma Investments Trust (10% Owner)	Buy	84,500	4.50	379,827
2012-05-17	Lerner Richard A (Director)	Buy	4,400	4.50	19,791

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Insider trading activities including stock purchases, stock sales, and option exercises of OPK listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Opko Health, Inc. (symbol OPK, CIK number 944809) see the Securities and Exchange Commission (SEC) website.

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