Insider Trading activities at Ionis Pharmaceuticals Inc (IONS) , Part 5

Insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Ionis Pharmaceuticals Inc (IONS) since 2015 are shown in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Ionis Pharmaceuticals Inc. (See page 1 of this report.) Table 2 shows the detailed insider transactions. This company's CIK number is 874015.

Total stock buying since 2015: $477,900.
Total stock sales since 2015: $220,707,715.
Total stock option exercises since 2015: $87,022,179.


27 insiders reported insider trading activities at Ionis Pharmaceuticals Inc (IONS):
Insider trading activities of Castleman Breaux
Insider trading activities of Devers Shannon L.
Insider trading activities of Reikes Peter N
Insider trading activities of Crooke Stanley T
Insider trading activities of Herman Joan E
Insider trading activities of O'neil Patrick R.
Insider trading activities of Loscalzo Joseph
Insider trading activities of Jenne Kyle
Insider trading activities of Hayden Michael R
Insider trading activities of Diaz Allene M.
Insider trading activities of Boyce Sarah
Insider trading activities of Schneider Eugene
Insider trading activities of Klein Joseph Iii
Insider trading activities of Birchler Brian
Insider trading activities of Monia Brett P
Insider trading activities of Yang Michael J.
Insider trading activities of Mcdevitt Damien
Insider trading activities of Bennett C Frank
Insider trading activities of Muto Frederick T
Insider trading activities of Cadoret-manier Onaiza
Insider trading activities of Parshall B Lynne
Insider trading activities of Wender Joseph H
Insider trading activities of Hougen Elizabeth L
Insider trading activities of Swayze Eric
Insider trading activities of Berthelsen Spencer R
Insider trading activities of Geary Richard S
Insider trading activities of Baroldi Joseph

Table 1. Yearly summary of insider stock purchases, sales, and option exercises at Ionis Pharmaceuticals Inc (IONS).
Insider Buying Insider Sales Option Exercises
Year Shares Value Shares Value Shares Value
2025 15,000 $477,900 993,870 $54,623,894 1,107,680 $26,972,189
2024 0 $0 216,854 $10,417,483 306,713 $1,690,800
2023 0 $0 480,350 $22,469,267 633,770 $17,444,961
2022 0 $0 9,319 $373,594 272,987 $291,150
2021 0 $0 128,563 $7,483,627 277,627 $139,500
2020 0 $0 435,149 $22,468,509 430,271 $8,790,881
2019 0 $0 528,804 $37,414,368 631,186 $18,611,478
2018 0 $0 237,729 $11,778,492 331,168 $2,959,654
2017 0 $0 327,296 $17,001,714 394,558 $3,417,846
2016 0 $0 240,936 $9,522,537 302,772 $2,241,037
2015 0 $0 422,957 $27,154,230 458,215 $4,462,683


Table 3. Detailed insider trading at Ionis Pharmaceuticals Inc (IONS) , Part 5
  Trade Date   Insider Name Trade Type     Shares       Price ($)   Value ($)
2017-10-05 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 9.04 9,035
2017-10-04 Crooke Stanley T (Chairman and CEO) Sale 11,000 54.23 596,475
2017-10-04 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.97 120,670
2017-10-02 Crooke Stanley T (Chairman and CEO) Sale 16,500 52.00 858,000
2017-10-02 Crooke Stanley T (Chairman and CEO) Option Ex 16,500 10.97 181,005
2017-09-06 O'neil Patrick R. (SVP, Legal and General Counsel) Sale 800 55.00 44,000
2017-09-06 O'neil Patrick R. (SVP, Legal and General Counsel) Option Ex 800 7.25 5,800
2017-09-05 O'neil Patrick R. (SVP, Legal and General Counsel) Sale 200 55.00 11,000
2017-09-05 O'neil Patrick R. (SVP, Legal and General Counsel) Option Ex 200 7.25 1,450
2017-07-24 Bennett C Frank (SVP, Antisense Research) Sale 10,000 59.29 592,900
2017-07-24 Bennett C Frank (SVP, Antisense Research) Option Ex 10,000 10.29 102,899
2017-07-20 Crooke Stanley T (Chairman and CEO) Sale 11,000 55.35 608,850
2017-07-20 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.97 120,670
2017-07-17 Crooke Stanley T (Chairman and CEO) Sale 16,500 52.45 865,425
2017-07-17 Crooke Stanley T (Chairman and CEO) Option Ex 16,500 10.97 181,005
2017-07-03 Monia Brett P (SVP, Antisense Drug Discovery) Sale 309 51.35 15,867
2017-07-03 Crooke Stanley T (Chairman and CEO) Sale 16,500 52.16 860,640
2017-07-03 Crooke Stanley T (Chairman and CEO) Option Ex 16,500 9.73 160,545
2017-07-02 Klein Joseph Iii (Director) Option Ex 2,469 .00 0
2017-07-01 Castleman Breaux (Director) Option Ex 3,406 .00 0
2017-07-01 Loscalzo Joseph (Director) Option Ex 2,001 .00 0
2017-07-01 Muto Frederick T (Director) Option Ex 2,469 .00 0
2017-07-01 Berthelsen Spencer R (Director) Option Ex 2,469 .00 0
2017-07-01 Wender Joseph H (Director) Option Ex 2,469 .00 0
2017-06-01 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 70 48.00 3,360
2017-06-01 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 70 10.82 757
2017-05-31 Muto Frederick T (Director) Sale 12,500 45.22 565,250
2017-05-31 Muto Frederick T (Director) Option Ex 12,500 9.77 122,125
2017-05-01 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 650 48.75 31,687
2017-05-01 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 500 10.82 5,410
2017-04-25 Crooke Stanley T (Chairman and CEO) Sale 16,500 47.81 788,865
2017-04-25 Crooke Stanley T (Chairman and CEO) Option Ex 16,500 7.25 119,625
2017-04-24 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 500 45.00 22,500
2017-04-24 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 500 10.82 5,410
2017-04-19 Crooke Stanley T (Chairman and CEO) Sale 5,500 43.25 237,875
2017-04-19 Crooke Stanley T (Chairman and CEO) Option Ex 5,500 7.25 39,875
2017-04-13 Crooke Stanley T (Chairman and CEO) Sale 11,000 41.30 454,299
2017-04-13 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 8.26 90,893
2017-04-12 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 40.07 40,070
2017-04-12 Crooke Stanley T (Chairman and CEO) Sale 11,000 40.07 440,770
2017-04-12 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 8.77 96,470
2017-03-03 Bennett C Frank (SVP, Antisense Research) Sale 5,000 55.00 275,000
2017-03-03 Bennett C Frank (SVP, Antisense Research) Option Ex 5,000 10.29 51,449
2017-03-02 Crooke Stanley T (Chairman and CEO) Sale 12,100 51.05 617,705
2017-03-02 Crooke Stanley T (Chairman and CEO) Option Ex 12,100 8.77 106,117
2017-03-01 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,500 49.29 73,935
2017-03-01 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 500 10.82 5,410
2017-03-01 Parshall B Lynne (COO) Sale 4,625 49.26 227,827
2017-03-01 Parshall B Lynne (COO) Option Ex 4,625 14.69 67,941
2017-02-24 Berthelsen Spencer R (Director) Option Ex 12,500 9.77 122,125
2017-02-06 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,500 46.34 69,502
2017-02-06 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 500 9.04 4,517
2017-02-03 Loscalzo Joseph (Director) Option Ex 937 .00 0
2017-01-17 Boyce Sarah (Chief Business Officer) Sale 1,361 46.29 63,000
2017-01-17 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 2,246 46.29 103,969
2017-01-17 Monia Brett P (SVP, Antisense Drug Discovery) Sale 2,502 46.29 115,817
2017-01-17 Geary Richard S (SVP, Development) Sale 2,441 46.29 112,996
2017-01-17 Hougen Elizabeth L (SVP, Finance & CFO) Sale 2,273 46.29 105,219
2017-01-17 Bennett C Frank (SVP, Antisense Research) Sale 2,421 46.29 112,068
2017-01-17 Parshall B Lynne (COO) Sale 7,246 46.29 335,417
2017-01-17 Crooke Stanley T (Chairman and CEO) Sale 15,957 46.29 738,649
2017-01-15 Boyce Sarah (Chief Business Officer) Option Ex 3,483 .00 0
2017-01-15 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 5,745 .00 0
2017-01-15 Monia Brett P (SVP, Antisense Drug Discovery) Option Ex 6,402 .00 0
2017-01-15 Geary Richard S (SVP, Development) Option Ex 6,246 .00 0
2017-01-15 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 5,814 .00 0
2017-01-15 Bennett C Frank (SVP, Antisense Research) Option Ex 6,195 .00 0
2017-01-15 Parshall B Lynne (COO) Option Ex 16,033 .00 0
2017-01-15 Crooke Stanley T (Chairman and CEO) Option Ex 29,834 .00 0
2017-01-10 Crooke Stanley T (Chairman and CEO) Sale 13,200 49.25 650,100
2017-01-10 Crooke Stanley T (Chairman and CEO) Option Ex 13,200 8.77 115,764
2017-01-04 Crooke Stanley T (Chairman and CEO) Sale 7,700 50.10 385,770
2017-01-04 Crooke Stanley T (Chairman and CEO) Option Ex 7,700 8.77 67,529
2017-01-03 Monia Brett P (SVP, Antisense Drug Discovery) Sale 309 48.60 15,017
2017-01-03 Crooke Stanley T (Chairman and CEO) Sale 11,000 48.05 528,550
2017-01-03 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 8.77 96,470
2016-12-20 Monia Brett P (SVP, Antisense Drug Discovery) Sale 130 52.48 6,822
2016-12-15 Parshall B Lynne (COO) Sale 4,000 50.00 200,000
2016-12-15 Parshall B Lynne (COO) Option Ex 4,000 7.25 29,000
2016-12-05 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 350 45.00 15,750
2016-12-05 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 350 10.82 3,787
2016-12-05 Hougen Elizabeth L (SVP, Finance & CFO) Sale 2,500 46.05 115,125
2016-12-05 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 2,500 11.27 28,175
2016-12-01 Parshall B Lynne (COO) Sale 12,500 42.33 529,125
2016-12-01 Parshall B Lynne (COO) Option Ex 12,500 14.69 183,625
2016-11-14 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 45.00 45,000
2016-11-14 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 10.82 10,820
2016-11-14 Hougen Elizabeth L (SVP, Finance & CFO) Sale 2,500 47.50 118,750
2016-11-14 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 2,500 11.27 28,175
2016-11-11 Hougen Elizabeth L (SVP, Finance & CFO) Sale 2,500 41.00 102,500
2016-11-11 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 2,500 11.27 28,175
2016-11-10 Crooke Stanley T (Chairman and CEO) Sale 11,000 41.23 453,475
2016-11-10 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 8.77 96,470
2016-11-09 Hougen Elizabeth L (SVP, Finance & CFO) Sale 2,500 38.49 96,225
2016-11-09 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 2,500 11.27 28,175
2016-11-09 Bennett C Frank (SVP, Antisense Research) Sale 22,805 36.31 828,049
2016-11-09 Bennett C Frank (SVP, Antisense Research) Option Ex 22,805 11.27 257,012
2016-11-09 Crooke Stanley T (Chairman and CEO) Sale 22,000 36.50 803,000
2016-11-09 Crooke Stanley T (Chairman and CEO) Option Ex 22,000 9.68 213,004
2016-11-07 Bennett C Frank (SVP, Antisense Research) Sale 5,000 34.00 170,000
2016-11-07 Bennett C Frank (SVP, Antisense Research) Option Ex 5,000 11.27 56,350
2016-10-05 Crooke Stanley T (Chairman and CEO) Sale 11,000 36.61 402,710
2016-10-05 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.29 113,189
2016-09-27 Crooke Stanley T (Chairman and CEO) Sale 22,000 36.03 792,769
2016-09-27 Crooke Stanley T (Chairman and CEO) Option Ex 22,000 10.29 226,379
2016-09-21 Crooke Stanley T (Chairman and CEO) Sale 22,000 35.50 781,000
2016-09-21 Crooke Stanley T (Chairman and CEO) Option Ex 22,000 10.29 226,379
2016-09-01 Parshall B Lynne (COO) Sale 12,500 29.93 374,162
2016-09-01 Parshall B Lynne (COO) Option Ex 12,500 10.97 137,125
2016-07-02 Klein Joseph Iii (Director) Option Ex 312 .00 0
2016-07-02 Muto Frederick T (Director) Option Ex 312 .00 0
2016-07-02 Berthelsen Spencer R (Director) Option Ex 312 .00 0
2016-07-02 Wender Joseph H (Director) Option Ex 312 .00 0
2016-07-01 Castleman Breaux (Director) Option Ex 2,740 .00 0
2016-07-01 Loscalzo Joseph (Director) Option Ex 1,334 .00 0
2016-07-01 Klein Joseph Iii (Director) Option Ex 1,803 .00 0
2016-07-01 Muto Frederick T (Director) Option Ex 1,803 .00 0
2016-07-01 Berthelsen Spencer R (Director) Option Ex 1,803 .00 0
2016-07-01 Wender Joseph H (Director) Option Ex 1,803 .00 0
2016-05-31 Muto Frederick T (Director) Sale 12,500 22.31 278,900
2016-05-31 Muto Frederick T (Director) Option Ex 12,500 5.93 74,125
2016-04-06 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 45.00 45,000
2016-04-06 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 10.82 10,820
2016-04-06 Crooke Stanley T (Chairman and CEO) Sale 11,000 46.12 507,375
2016-04-06 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.29 113,189
2016-03-31 Crooke Stanley T (Chairman and CEO) Sale 11,000 40.73 448,085
2016-03-31 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.02 110,242
2016-03-23 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 45.40 45,400
2016-03-23 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 10.82 10,820
2016-02-19 Berthelsen Spencer R (Director) Option Ex 12,500 5.93 74,125
2016-02-03 Loscalzo Joseph (Director) Option Ex 938 .00 0
2016-01-19 Boyce Sarah (Chief Business Officer) Sale 872 41.46 36,150
2016-01-19 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,871 41.46 77,571
2016-01-19 Monia Brett P (SVP, Antisense Drug Discovery) Sale 2,208 41.46 91,545
2016-01-19 Geary Richard S (SVP, Development) Sale 2,162 41.46 89,634
2016-01-19 Hougen Elizabeth L (SVP, Finance & CFO) Sale 1,899 41.46 78,740
2016-01-19 Bennett C Frank (SVP, Antisense Research) Sale 2,110 41.46 87,474
2016-01-19 Parshall B Lynne (COO & Secretary) Sale 5,192 41.46 215,260
2016-01-19 Crooke Stanley T (Chairman and CEO) Sale 13,401 41.46 555,605
2016-01-15 Boyce Sarah (Chief Business Officer) Option Ex 2,188 .00 0
2016-01-15 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 4,693 .00 0
2016-01-15 Monia Brett P (SVP, Antisense Drug Discovery) Option Ex 5,543 .00 0
2016-01-15 Geary Richard S (SVP, Development) Option Ex 5,427 .00 0
2016-01-15 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 4,762 .00 0
2016-01-15 Bennett C Frank (SVP, Antisense Research) Option Ex 5,295 .00 0
2016-01-15 Parshall B Lynne (COO & Secretary) Option Ex 13,267 .00 0
2016-01-15 Crooke Stanley T (Chairman and CEO) Option Ex 24,661 .00 0
2016-01-05 Crooke Stanley T (Chairman and CEO) Sale 5,500 62.10 341,550
2016-01-05 Crooke Stanley T (Chairman and CEO) Option Ex 5,500 9.76 53,652
2016-01-04 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 61.10 61,100

Insider trading activities including stock purchases, stock sales, and option exercises of IONS listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Ionis Pharmaceuticals Inc (symbol IONS, CIK number 874015) see the Securities and Exchange Commission (SEC) website.



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