Insider Trading History of Baker Bros. Advisors (gp) Llc

The following table details the insider trading activities (stock purchases, stock sales, and stock option exercises) of Baker Bros. Advisors (gp) Llc since 2014. This trader's CIK number is 1580575. At the time of last reporting, Baker Bros. Advisors (gp) Llc was the Officer of Igm Biosciences, Inc.. (stock ticker symbol IGMS). Also see all insider trading activities at Igm Biosciences, Inc..

Note that in the past Baker Bros. Advisors (GP) LLC also reported insider trading activities as an insider of the following companies:

Yearly summary of insider trading at Genomic Health Inc (GHDX) by Baker Bros. Advisors (gp) Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2019	GHDX	0	$0	303,067	$22,016,767	16,500	$290,235
2018	GHDX	0	$0	265,680	$19,930,895	0	$0

Yearly summary of insider trading at Entrada Therapeutics, Inc. (TRDA) by Baker Bros. Advisors (gp) Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2022	TRDA	161,400	$973,801	0	$0	0	$0

Yearly summary of insider trading at Neoleukin Therapeutics, Inc. (NLTX) by Baker Bros. Advisors (gp) Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2019	NLTX	3,017,542	$25,347,352	0	$0	0	$0

Yearly summary of insider trading at Mirati Therapeutics, Inc. (MRTX) by Baker Bros. Advisors (gp) Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	MRTX	0	$0	999,358	$9,418,556	0	$0
2015	MRTX	150,000	$6,750,000	0	$0	0	$0

Yearly summary of insider trading at Acadia Pharmaceuticals Inc (ACAD) by Baker Bros. Advisors (gp) Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	ACAD	1,449,090	$38,856,402	0	$0	0	$0
2014	ACAD	526,316	$15,000,006	0	$0	0	$0

Yearly summary of insider trading at Invitae Corp (NVTA) by Baker Bros. Advisors (gp) Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	NVTA	733,333	$4,399,998	0	$0	0	$0

Yearly summary of insider trading at Seagen Inc. (SGEN) by Baker Bros. Advisors (gp) Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2023	SGEN	0	$0	0	$0	17,500	$642,250
2022	SGEN	0	$0	0	$0	35,000	$702,100

Yearly summary of insider trading at Bellicum Pharmaceuticals, Inc (BLCM) by Baker Bros. Advisors (gp) Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2017	BLCM	166,666	$1,999,992	0	$0	0	$0

Yearly summary of insider trading at Incyte Corp (INCY) by Baker Bros. Advisors (gp) Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	INCY	800,000	$50,975,199	0	$0	60,000	$231,600
2015	INCY	0	$0	0	$0	4,683,926	$460,800
2014	INCY	0	$0	0	$0	30,000	$210,600

Yearly summary of insider trading at Trimeris Inc (GEVA) by Baker Bros. Advisors (gp) Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2015	GEVA	1,000,000	$94,190,000	0	$0	0	$0

Yearly summary of insider trading at Aceragen, Inc. (IDRA) by Baker Bros. Advisors (gp) Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2015	IDRA	5,333,333	$19,999,998	0	$0	0	$0

Yearly summary of insider trading at Intellia Therapeutics, Inc. (NTLA) by Baker Bros. Advisors (gp) Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	NTLA	200,000	$3,600,000	0	$0	0	$0

Yearly summary of insider trading at Atreca, Inc. (BCEL) by Baker Bros. Advisors (gp) Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2023	BCEL	0	$0	274,739	$110,719	0	$0

Yearly summary of insider trading at Igm Biosciences, Inc. (IGMS) by Baker Bros. Advisors (gp) Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2024	IGMS	395,317	$3,425,721	0	$0	0	$0
2023	IGMS	532,693	$3,390,965	0	$0	0	$0

Insider trading activities at 14 companies by Baker Bros. Advisors (gp) Llc:

1. Genomic Health Inc (GHDX)

2. Entrada Therapeutics, Inc. (TRDA)

3. Neoleukin Therapeutics, Inc. (NLTX)

4. Mirati Therapeutics, Inc. (MRTX)

5. Acadia Pharmaceuticals Inc (ACAD)

6. Invitae Corp (NVTA)

7. Seagen Inc. (SGEN)

8. Bellicum Pharmaceuticals, Inc (BLCM)

9. Incyte Corp (INCY)

10. Trimeris Inc (GEVA)

11. Aceragen, Inc. (IDRA)

12. Intellia Therapeutics, Inc. (NTLA)

13. Atreca, Inc. (BCEL)

14. Igm Biosciences, Inc. (IGMS)

Table 1. Insider trading of Genomic Health Inc (GHDX) by Baker Bros. Advisors (gp) Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2019-02-27	GHDX	Sale	39,109	76.43	2,989,139
2019-02-26	GHDX	Option Ex	16,500	17.59	290,235
2019-02-26	GHDX	Sale	8,650	77.97	674,440
2019-01-28	GHDX	Sale	46,477	70.95	3,297,636
2019-01-23	GHDX	Sale	37,512	71.99	2,700,338
2019-01-24	GHDX	Sale	79,403	72.02	5,718,604
2019-01-25	GHDX	Sale	91,916	72.20	6,636,610
2018-11-26	GHDX	Sale	39,675	74.20	2,944,043
2018-11-27	GHDX	Sale	138,610	74.00	10,257,001
2018-11-16	GHDX	Sale	87,395	77.00	6,729,851

Table 2. Insider trading of Entrada Therapeutics, Inc. (TRDA) by Baker Bros. Advisors (gp) Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2022-06-06	TRDA	Buy	38,304	6.39	244,685
2022-06-02	TRDA	Buy	2,643	5.82	15,382
2022-05-20	TRDA	Buy	16,849	5.84	98,431
2022-05-24	TRDA	Buy	23,823	5.84	139,031
2022-05-23	TRDA	Buy	7,837	5.99	46,920
2022-05-16	TRDA	Buy	19,000	5.83	110,694
2022-05-17	TRDA	Buy	18,511	6.13	113,472
2022-05-18	TRDA	Buy	34,433	5.96	205,186

Table 3. Insider trading of Neoleukin Therapeutics, Inc. (NLTX) by Baker Bros. Advisors (gp) Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2019-12-20	NLTX	Buy	3,017,542	8.40	25,347,352

Table 4. Insider trading of Mirati Therapeutics, Inc. (MRTX) by Baker Bros. Advisors (gp) Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-06-07	MRTX	Sale	296,200	9.44	2,795,535
2016-06-08	MRTX	Sale	158,100	9.21	1,456,417
2016-06-09	MRTX	Sale	545,058	9.48	5,166,604
2015-09-16	MRTX	Buy	150,000	45.00	6,750,000

Table 5. Insider trading of Acadia Pharmaceuticals Inc (ACAD) by Baker Bros. Advisors (gp) Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-03-30	ACAD	Buy	462,546	26.08	12,064,124
2016-04-01	ACAD	Buy	302,900	28.18	8,536,933
2016-03-31	ACAD	Buy	683,644	26.70	18,255,345
2014-03-05	ACAD	Buy	526,316	28.50	15,000,006

Table 6. Insider trading of Invitae Corp (NVTA) by Baker Bros. Advisors (gp) Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-11-17	NVTA	Buy	733,333	6.00	4,399,998

Table 7. Insider trading of Seagen Inc. (SGEN) by Baker Bros. Advisors (gp) Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2023-05-01	SGEN	Option Ex	17,500	36.70	642,250
2022-03-08	SGEN	Option Ex	35,000	20.06	702,100

Table 8. Insider trading of Bellicum Pharmaceuticals, Inc (BLCM) by Baker Bros. Advisors (gp) Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2017-03-24	BLCM	Buy	166,666	12.00	1,999,992

Table 9. Insider trading of Incyte Corp (INCY) by Baker Bros. Advisors (gp) Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-03-15	INCY	Buy	400,000	66.08	26,431,599
2016-03-17	INCY	Buy	400,000	61.36	24,543,600
2016-03-17	INCY	Option Ex	60,000	3.86	231,600
2015-09-16	INCY	Option Ex	4,623,926	.00	0
2015-05-11	INCY	Option Ex	60,000	7.68	460,800
2014-05-21	INCY	Option Ex	30,000	7.02	210,600

Table 10. Insider trading of Trimeris Inc (GEVA) by Baker Bros. Advisors (gp) Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2015-01-07	GEVA	Buy	1,000,000	94.19	94,190,000

Table 11. Insider trading of Aceragen, Inc. (IDRA) by Baker Bros. Advisors (gp) Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2015-02-13	IDRA	Buy	5,333,333	3.75	19,999,998

Table 12. Insider trading of Intellia Therapeutics, Inc. (NTLA) by Baker Bros. Advisors (gp) Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-05-11	NTLA	Buy	200,000	18.00	3,600,000

Table 13. Insider trading of Atreca, Inc. (BCEL) by Baker Bros. Advisors (gp) Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2023-10-19	BCEL	Sale	274,739	.40	110,719

Table 14. Insider trading of Igm Biosciences, Inc. (IGMS) by Baker Bros. Advisors (gp) Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2024-03-27	IGMS	Buy	27,844	9.24	257,389
2024-03-28	IGMS	Buy	97,473	9.62	937,592
2024-03-26	IGMS	Buy	270,000	8.26	2,230,740
2023-12-15	IGMS	Buy	288,007	6.44	1,854,765
2023-12-13	IGMS	Buy	87,316	5.88	512,981
2023-12-14	IGMS	Buy	157,370	6.50	1,023,219

Insider trading activities including stock purchases, stock sales, and option exercises listed in the above table cannot be completely guaranteed as to their accuracy. For more information regarding the trades made by Baker Bros. Advisors (gp) Llc (Officer of Igm Biosciences, Inc. at the time of this reporting) see the Securities and Exchange Commission (SEC) website.

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