Insider Trading History of Novo Holdings A/s

The following table details the insider trading activities (stock purchases, stock sales, and stock option exercises) of Novo Holdings A/s since 2007. This trader's CIK number is 1388325. At the time of last reporting, Novo Holdings A/s was the Officer of Io Biotech, Inc.. (stock ticker symbol IOBT). Also see all insider trading activities at Io Biotech, Inc..

Note that in the past Novo Holdings A/S also reported insider trading activities as an insider of the following companies:

Yearly summary of insider trading at Ra Pharmaceuticals, Inc. (RARX) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	RARX	246,154	$3,200,002	0	$0	0	$0

Yearly summary of insider trading at Galera Therapeutics, Inc. (GRTX) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2021	GRTX	0	$0	500,000	$5,290,000	0	$0
2020	GRTX	0	$0	450,000	$4,950,000	0	$0
2019	GRTX	500,000	$6,000,000	0	$0	0	$0

Yearly summary of insider trading at Colucid Pharmaceuticals, Inc. (CLCD) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	CLCD	100,000	$2,000,000	0	$0	0	$0
2015	CLCD	1,300,000	$13,000,000	0	$0	0	$0

Yearly summary of insider trading at Iveric Bio, Inc. (OPHT) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	OPHT	0	$0	4,910,487	$81,299,969	0	$0
2015	OPHT	0	$0	1,005,000	$52,008,750	0	$0
2014	OPHT	0	$0	995,000	$39,999,000	0	$0
2013	OPHT	455,000	$10,010,000	0	$0	0	$0

Yearly summary of insider trading at Inozyme Pharma, Inc. (INZY) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2021	INZY	0	$0	375,000	$7,875,000	0	$0
2020	INZY	375,000	$6,000,000	0	$0	0	$0

Yearly summary of insider trading at Checkmate Pharmaceuticals, Inc. (CMPI) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	CMPI	500,000	$7,500,000	0	$0	0	$0

Yearly summary of insider trading at Anaptysbio, Inc (ANAB) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2017	ANAB	50,000	$750,000	1,096,900	$23,757,058	0	$0

Yearly summary of insider trading at Entasis Therapeutics Holdings Inc. (ETTX) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2018	ETTX	1,089,835	$16,347,525	0	$0	0	$0

Yearly summary of insider trading at Metagenomi, Inc. (MGX) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2024	MGX	900,000	$13,025,000	0	$0	0	$0

Yearly summary of insider trading at Galecto, Inc. (GLTO) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	GLTO	333,333	$4,999,995	0	$0	0	$0

Yearly summary of insider trading at Arcellx, Inc. (ACLX) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2022	ACLX	833,333	$12,499,995	0	$0	0	$0

Yearly summary of insider trading at Htg Molecular Diagnostics, Inc (HTGM) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2017	HTGM	0	$0	1,230,399	$2,252,880	0	$0
2015	HTGM	365,106	$5,111,484	0	$0	0	$0

Yearly summary of insider trading at Nkarta, Inc. (NKTX) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	NKTX	555,555	$9,999,990	0	$0	0	$0

Yearly summary of insider trading at Harmony Biosciences Holdings, Inc. (HRMY) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	HRMY	132,503	$3,180,072	0	$0	0	$0

Yearly summary of insider trading at Regado Biosciences Inc (TBRA) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	TBRA	0	$0	595,500	$5,945,756	0	$0
2015	TBRA	838,041	$8,899,995	225,000	$2,203,106	0	$0

Yearly summary of insider trading at Inogen Inc (INGN) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2021	INGN	0	$0	1,470,000	$77,687,600	0	$0
2014	INGN	0	$0	2,617,000	$52,180,960	0	$0

Yearly summary of insider trading at Apollo Endosurgery, Inc. (APEN) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2017	APEN	0	$0	155,130	$936,474	0	$0

Yearly summary of insider trading at Akebia Therapeutics, Inc. (AKBA) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2014	AKBA	182,590	$3,104,030	0	$0	0	$0

Yearly summary of insider trading at Cyteir Therapeutics, Inc. (CYT) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2023	CYT	0	$0	418,277	$1,060,757	0	$0
2022	CYT	0	$0	900,000	$2,700,000	0	$0

Yearly summary of insider trading at Eargo, Inc. (EAR) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	EAR	150,000	$2,700,000	0	$0	0	$0

Yearly summary of insider trading at Irhythm Technologies, Inc. (IRTC) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	IRTC	100,000	$1,700,000	0	$0	0	$0

Yearly summary of insider trading at Alder Biopharmaceuticals Inc (ALDR) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2014	ALDR	550,000	$5,500,000	0	$0	0	$0

Yearly summary of insider trading at Kalvista Pharmaceuticals, Inc. (KALV) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2017	KALV	0	$0	2,901,930	$30,003,759	0	$0

Yearly summary of insider trading at Disc Medicine, Inc. (IRON) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2023	IRON	0	$0	1,250,000	$57,625,000	0	$0

Yearly summary of insider trading at Bolt Biotherapeutics, Inc. (BOLT) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2022	BOLT	0	$0	800,000	$1,600,000	0	$0
2021	BOLT	400,000	$8,000,000	0	$0	0	$0

Yearly summary of insider trading at Milestone Pharmaceuticals Inc. (MIST) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2019	MIST	333,333	$4,999,995	240,000	$3,840,000	2,341,137	$0

Yearly summary of insider trading at Minerva Surgical Inc (UTRS) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2021	UTRS	580,000	$6,960,000	0	$0	0	$0

Yearly summary of insider trading at Nevro Corp (NVRO) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2014	NVRO	215,000	$3,870,000	0	$0	0	$0

Yearly summary of insider trading at Reata Pharmaceuticals Inc (RETA) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2017	RETA	0	$0	373,000	$9,779,135	0	$0
2016	RETA	750,000	$8,250,000	0	$0	0	$0

Yearly summary of insider trading at Edgewise Therapeutics, Inc. (EWTX) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2022	EWTX	484,496	$4,999,998	0	$0	0	$0
2021	EWTX	625,000	$10,000,000	0	$0	0	$0

Yearly summary of insider trading at Otonomy, Inc. (OTIC) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2014	OTIC	187,565	$2,993,132	0	$0	0	$0

Yearly summary of insider trading at Morphic Holding, Inc. (MORF) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2019	MORF	666,667	$10,000,005	0	$0	0	$0

Yearly summary of insider trading at Reneo Pharmaceuticals, Inc. (RPHM) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2023	RPHM	0	$0	100,000	$709,700	0	$0
2021	RPHM	666,666	$9,999,990	0	$0	0	$0

Yearly summary of insider trading at Biomimetic Therapeutics, Inc. (BMTI) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2010	BMTI	1,000,000	$8,500,000	0	$0	0	$0
2009	BMTI	393,406	$3,400,351	0	$0	0	$0
2008	BMTI	905,870	$9,463,588	0	$0	0	$0
2007	BMTI	335,575	$4,180,257	0	$0	0	$0

Yearly summary of insider trading at Spruce Biosciences, Inc. (SPRB) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2024	SPRB	0	$0	4,172,336	$3,407,836	0	$0
2023	SPRB	2,208,000	$6,999,360	0	$0	0	$0
2020	SPRB	250,000	$3,750,000	0	$0	0	$0

Yearly summary of insider trading at Flexion Therapeutics Inc (FLXN) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2015	FLXN	0	$0	150,000	$3,091,989	0	$0
2014	FLXN	1,192,308	$17,500,004	0	$0	0	$0

Yearly summary of insider trading at Corvus Pharmaceuticals, Inc. (CRVS) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	CRVS	0	$0	1,538,062	$8,168,302	0	$0
2019	CRVS	0	$0	1,492,956	$6,077,862	0	$0
2018	CRVS	1,176,470	$9,999,995	0	$0	0	$0
2017	CRVS	20,000	$219,000	0	$0	0	$0
2016	CRVS	666,666	$9,999,990	0	$0	0	$0

Yearly summary of insider trading at Verve Therapeutics, Inc. (VERV) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2021	VERV	350,000	$6,650,000	0	$0	0	$0

Yearly summary of insider trading at Io Biotech, Inc. (IOBT) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2024	IOBT	0	$0	1,392,618	$1,889,739	0	$0
2023	IOBT	2,469,135	$4,999,998	0	$0	0	$0
2021	IOBT	325,000	$4,550,000	0	$0	0	$0

Yearly summary of insider trading at Zs Pharma, Inc. (ZSPH) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2014	ZSPH	275,000	$4,950,000	0	$0	0	$0

Yearly summary of insider trading at Mirum Pharmaceuticals, Inc. (MIRM) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2019	MIRM	575,000	$8,625,000	0	$0	0	$0

Yearly summary of insider trading at Aligos Therapeutics, Inc. (ALGS) by Novo Holdings A/s

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	ALGS	200,000	$3,000,000	0	$0	0	$0

Insider trading activities at 42 companies by Novo Holdings A/s:

1. Ra Pharmaceuticals, Inc. (RARX)

2. Galera Therapeutics, Inc. (GRTX)

3. Colucid Pharmaceuticals, Inc. (CLCD)

4. Iveric Bio, Inc. (OPHT)

5. Inozyme Pharma, Inc. (INZY)

6. Checkmate Pharmaceuticals, Inc. (CMPI)

7. Anaptysbio, Inc (ANAB)

8. Entasis Therapeutics Holdings Inc. (ETTX)

9. Metagenomi, Inc. (MGX)

10. Galecto, Inc. (GLTO)

11. Arcellx, Inc. (ACLX)

12. Htg Molecular Diagnostics, Inc (HTGM)

13. Nkarta, Inc. (NKTX)

14. Harmony Biosciences Holdings, Inc. (HRMY)

15. Regado Biosciences Inc (TBRA)

16. Inogen Inc (INGN)

17. Apollo Endosurgery, Inc. (APEN)

18. Akebia Therapeutics, Inc. (AKBA)

19. Cyteir Therapeutics, Inc. (CYT)

20. Eargo, Inc. (EAR)

21. Irhythm Technologies, Inc. (IRTC)

22. Alder Biopharmaceuticals Inc (ALDR)

23. Kalvista Pharmaceuticals, Inc. (KALV)

24. Disc Medicine, Inc. (IRON)

25. Bolt Biotherapeutics, Inc. (BOLT)

26. Milestone Pharmaceuticals Inc. (MIST)

27. Minerva Surgical Inc (UTRS)

28. Nevro Corp (NVRO)

29. Reata Pharmaceuticals Inc (RETA)

30. Edgewise Therapeutics, Inc. (EWTX)

31. Otonomy, Inc. (OTIC)

32. Morphic Holding, Inc. (MORF)

33. Reneo Pharmaceuticals, Inc. (RPHM)

34. Biomimetic Therapeutics, Inc. (BMTI)

35. Spruce Biosciences, Inc. (SPRB)

36. Flexion Therapeutics Inc (FLXN)

37. Corvus Pharmaceuticals, Inc. (CRVS)

38. Verve Therapeutics, Inc. (VERV)

39. Io Biotech, Inc. (IOBT)

40. Zs Pharma, Inc. (ZSPH)

41. Mirum Pharmaceuticals, Inc. (MIRM)

42. Aligos Therapeutics, Inc. (ALGS)

Table 1. Insider trading of Ra Pharmaceuticals, Inc. (RARX) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-10-31	RARX	Buy	246,154	13.00	3,200,002

Table 2. Insider trading of Galera Therapeutics, Inc. (GRTX) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2021-02-18	GRTX	Sale	500,000	10.58	5,290,000
2020-10-15	GRTX	Sale	450,000	11.00	4,950,000
2019-11-12	GRTX	Buy	500,000	12.00	6,000,000

Table 3. Insider trading of Colucid Pharmaceuticals, Inc. (CLCD) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-09-09	CLCD	Buy	100,000	20.00	2,000,000
2015-05-11	CLCD	Buy	1,300,000	10.00	13,000,000

Table 4. Insider trading of Iveric Bio, Inc. (OPHT) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-12-14	OPHT	Sale	2,205,000	4.97	10,963,260
2016-12-15	OPHT	Sale	1,405,487	4.72	6,636,709
2016-05-24	OPHT	Sale	1,300,000	49.00	63,700,000
2015-03-05	OPHT	Sale	1,005,000	51.75	52,008,750
2014-11-13	OPHT	Sale	995,000	40.20	39,999,000
2013-09-30	OPHT	Buy	455,000	22.00	10,010,000

Table 5. Insider trading of Inozyme Pharma, Inc. (INZY) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2021-01-28	INZY	Sale	375,000	21.00	7,875,000
2020-07-28	INZY	Buy	375,000	16.00	6,000,000

Table 6. Insider trading of Checkmate Pharmaceuticals, Inc. (CMPI) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-08-11	CMPI	Buy	500,000	15.00	7,500,000

Table 7. Insider trading of Anaptysbio, Inc (ANAB) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2017-08-21	ANAB	Sale	356,300	21.10	7,518,286
2017-08-14	ANAB	Sale	35,172	21.79	766,503
2017-08-15	ANAB	Sale	143,428	21.00	3,011,988
2017-08-04	ANAB	Sale	10,271	22.00	225,962
2017-08-07	ANAB	Sale	481,023	22.01	10,586,354
2017-08-03	ANAB	Sale	21,451	22.01	472,200
2017-08-02	ANAB	Sale	25,700	23.87	613,484
2017-08-01	ANAB	Sale	23,555	23.87	562,281
2017-01-31	ANAB	Buy	50,000	15.00	750,000

Table 8. Insider trading of Entasis Therapeutics Holdings Inc. (ETTX) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2018-09-28	ETTX	Buy	1,089,835	15.00	16,347,525

Table 9. Insider trading of Metagenomi, Inc. (MGX) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2024-02-13	MGX	Buy	800,000	15.00	12,000,000
2024-02-09	MGX	Buy	100,000	10.25	1,025,000

Table 10. Insider trading of Galecto, Inc. (GLTO) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-11-02	GLTO	Buy	333,333	15.00	4,999,995

Table 11. Insider trading of Arcellx, Inc. (ACLX) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2022-02-08	ACLX	Buy	833,333	15.00	12,499,995

Table 12. Insider trading of Htg Molecular Diagnostics, Inc (HTGM) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2017-08-24	HTGM	Sale	382,437	1.91	730,072
2017-08-23	HTGM	Sale	47,162	2.02	95,455
2017-08-25	HTGM	Sale	720,214	1.75	1,260,374
2017-08-18	HTGM	Sale	55,100	2.10	115,599
2017-08-21	HTGM	Sale	12,845	2.02	25,972
2017-08-22	HTGM	Sale	12,641	2.01	25,408
2015-05-11	HTGM	Buy	365,106	14.00	5,111,484

Table 13. Insider trading of Nkarta, Inc. (NKTX) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-07-14	NKTX	Buy	555,555	18.00	9,999,990

Table 14. Insider trading of Harmony Biosciences Holdings, Inc. (HRMY) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-08-21	HRMY	Buy	132,503	24.00	3,180,072

Table 15. Insider trading of Regado Biosciences Inc (TBRA) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-07-11	TBRA	Sale	20,431	12.19	249,094
2016-07-12	TBRA	Sale	8,752	12.12	106,074
2016-07-13	TBRA	Sale	29,884	11.88	354,932
2016-07-06	TBRA	Sale	59,850	12.20	730,289
2016-07-07	TBRA	Sale	21,869	12.03	263,149
2016-07-05	TBRA	Sale	10,400	12.57	130,707
2016-06-29	TBRA	Sale	16,068	12.63	202,954
2016-06-30	TBRA	Sale	27,133	12.58	341,360
2016-06-28	TBRA	Sale	23,613	14.03	331,172
2016-06-06	TBRA	Sale	187,500	10.37	1,944,000
2016-03-03	TBRA	Sale	25,000	6.86	171,400
2016-03-04	TBRA	Sale	55,000	6.54	359,645
2016-03-02	TBRA	Sale	110,000	6.92	760,980
2015-11-18	TBRA	Sale	153,601	9.76	1,498,684
2015-11-17	TBRA	Sale	71,399	9.87	704,422
2015-05-04	TBRA	Buy	838,041	10.62	8,899,995

Table 16. Insider trading of Inogen Inc (INGN) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2021-06-02	INGN	Sale	680,000	57.32	38,977,600
2021-03-01	INGN	Sale	790,000	49.00	38,710,000
2014-11-04	INGN	Sale	2,000,000	21.50	43,000,000
2014-02-20	INGN	Sale	617,000	14.88	9,180,960

Table 17. Insider trading of Apollo Endosurgery, Inc. (APEN) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2017-07-24	APEN	Sale	17,200	6.83	117,544
2017-07-25	APEN	Sale	24,504	6.96	170,596
2017-07-26	APEN	Sale	8,426	6.84	57,642
2017-05-10	APEN	Sale	1,500	5.74	8,608
2017-05-11	APEN	Sale	103,500	5.62	582,084

Table 18. Insider trading of Akebia Therapeutics, Inc. (AKBA) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2014-03-25	AKBA	Buy	182,590	17.00	3,104,030

Table 19. Insider trading of Cyteir Therapeutics, Inc. (CYT) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2023-07-20	CYT	Sale	100,000	2.75	275,100
2023-07-19	CYT	Sale	1,900	2.76	5,247
2023-07-17	CYT	Sale	21,100	2.75	58,003
2023-07-18	CYT	Sale	6,500	2.76	17,920
2023-07-14	CYT	Sale	11,000	2.74	30,107
2023-06-30	CYT	Sale	200,937	2.63	529,268
2023-06-27	CYT	Sale	31,978	1.77	56,696
2023-06-26	CYT	Sale	8,437	1.79	15,110
2023-06-21	CYT	Sale	4,834	1.99	9,638
2023-06-22	CYT	Sale	5,041	1.94	9,784
2023-06-23	CYT	Sale	3,423	1.88	6,445
2023-06-15	CYT	Sale	10,002	2.03	20,304
2023-06-20	CYT	Sale	744	2.12	1,573
2023-06-16	CYT	Sale	5,983	2.03	12,139
2023-06-12	CYT	Sale	900	2.06	1,858
2023-06-13	CYT	Sale	2,626	2.10	5,514
2023-06-14	CYT	Sale	2,872	2.11	6,051
2022-07-20	CYT	Sale	900,000	3.00	2,700,000

Table 20. Insider trading of Eargo, Inc. (EAR) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-10-20	EAR	Buy	150,000	18.00	2,700,000

Table 21. Insider trading of Irhythm Technologies, Inc. (IRTC) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-10-25	IRTC	Buy	100,000	17.00	1,700,000

Table 22. Insider trading of Alder Biopharmaceuticals Inc (ALDR) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2014-05-13	ALDR	Buy	550,000	10.00	5,500,000

Table 23. Insider trading of Kalvista Pharmaceuticals, Inc. (KALV) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2017-10-12	KALV	Sale	1,726,481	9.26	15,987,214
2017-10-10	KALV	Sale	963,283	12.78	12,309,793
2017-10-11	KALV	Sale	35,519	10.21	362,755
2017-09-13	KALV	Sale	25,900	8.02	207,614
2017-09-14	KALV	Sale	10,000	8.05	80,500
2017-09-15	KALV	Sale	140,747	7.50	1,055,883

Table 24. Insider trading of Disc Medicine, Inc. (IRON) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2023-06-28	IRON	Sale	1,250,000	46.10	57,625,000

Table 25. Insider trading of Bolt Biotherapeutics, Inc. (BOLT) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2022-07-13	BOLT	Sale	800,000	2.00	1,600,000
2021-02-09	BOLT	Buy	400,000	20.00	8,000,000

Table 26. Insider trading of Milestone Pharmaceuticals Inc. (MIST) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2019-11-25	MIST	Sale	240,000	16.00	3,840,000
2019-05-13	MIST	Buy	333,333	15.00	4,999,995
2019-05-13	MIST	Option Ex	2,341,137	.00	0

Table 27. Insider trading of Minerva Surgical Inc (UTRS) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2021-10-26	UTRS	Buy	580,000	12.00	6,960,000

Table 28. Insider trading of Nevro Corp (NVRO) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2014-11-12	NVRO	Buy	215,000	18.00	3,870,000

Table 29. Insider trading of Reata Pharmaceuticals Inc (RETA) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2017-06-13	RETA	Sale	11,389	25.47	290,077
2017-06-14	RETA	Sale	49,611	25.03	1,241,862
2017-06-12	RETA	Sale	90,303	25.28	2,282,859
2017-06-09	RETA	Sale	2,200	25.89	56,955
2017-06-08	RETA	Sale	130,000	26.00	3,380,000
2017-06-07	RETA	Sale	2,000	28.04	56,080
2017-06-05	RETA	Sale	23,327	28.67	668,831
2017-06-06	RETA	Sale	64,170	28.09	1,802,471
2016-06-01	RETA	Buy	750,000	11.00	8,250,000

Table 30. Insider trading of Edgewise Therapeutics, Inc. (EWTX) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2022-09-14	EWTX	Buy	484,496	10.32	4,999,998
2021-03-30	EWTX	Buy	625,000	16.00	10,000,000

Table 31. Insider trading of Otonomy, Inc. (OTIC) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2014-08-19	OTIC	Buy	15,690	15.50	243,132
2014-08-18	OTIC	Buy	171,875	16.00	2,750,000

Table 32. Insider trading of Morphic Holding, Inc. (MORF) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2019-06-28	MORF	Buy	666,667	15.00	10,000,005

Table 33. Insider trading of Reneo Pharmaceuticals, Inc. (RPHM) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2023-06-23	RPHM	Sale	100,000	7.10	709,700
2021-04-13	RPHM	Buy	666,666	15.00	9,999,990

Table 34. Insider trading of Biomimetic Therapeutics, Inc. (BMTI) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2010-07-15	BMTI	Buy	1,000,000	8.50	8,500,000
2009-06-25	BMTI	Buy	343,406	8.50	2,918,951
2009-01-29	BMTI	Buy	50,000	9.63	481,400
2008-11-11	BMTI	Buy	500	8.00	4,000
2008-09-09	BMTI	Buy	172	10.47	1,800
2008-09-08	BMTI	Buy	19,400	10.42	202,167
2008-09-08	BMTI	Buy	600	10.65	6,387
2008-09-05	BMTI	Buy	24,700	10.33	255,126
2008-09-04	BMTI	Buy	500	10.30	5,152
2008-09-04	BMTI	Buy	6,100	10.70	65,263
2008-09-04	BMTI	Buy	71,807	10.43	748,803
2008-09-03	BMTI	Buy	18,100	10.84	196,276
2008-08-29	BMTI	Buy	10,202	10.83	110,487
2008-09-02	BMTI	Buy	2,948	10.69	31,525
2008-09-02	BMTI	Buy	7,052	10.86	76,549
2008-08-27	BMTI	Buy	7,300	10.95	79,935
2008-08-28	BMTI	Buy	1,700	10.88	18,504
2008-07-07	BMTI	Buy	5,146	11.00	56,606
2008-06-24	BMTI	Buy	248,202	11.00	2,730,222
2008-05-22	BMTI	Buy	12,931	10.95	141,594
2008-05-13	BMTI	Buy	7,843	10.96	85,927
2008-05-09	BMTI	Buy	25,100	10.87	272,937
2008-05-08	BMTI	Buy	6,843	10.29	70,428
2008-05-07	BMTI	Buy	7,792	10.53	82,034
2008-05-08	BMTI	Buy	12,596	10.45	131,615
2008-05-07	BMTI	Buy	13,769	10.26	141,201
2008-05-08	BMTI	Buy	11,300	10.36	117,113
2008-05-06	BMTI	Buy	8,309	10.51	87,344
2008-05-06	BMTI	Buy	10,600	9.83	104,208
2008-05-06	BMTI	Buy	15,191	10.26	155,829
2008-05-05	BMTI	Buy	39,182	10.63	416,387
2008-05-02	BMTI	Buy	700	10.50	7,350
2008-04-29	BMTI	Buy	253,693	9.88	2,506,233
2008-04-28	BMTI	Buy	35,000	9.90	346,605
2008-04-28	BMTI	Buy	9,200	10.13	93,196
2008-04-25	BMTI	Buy	11,392	10.08	114,785
2007-01-25	BMTI	Buy	335,575	12.46	4,180,257

Table 35. Insider trading of Spruce Biosciences, Inc. (SPRB) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2024-03-21	SPRB	Sale	465,021	.76	351,090
2024-03-19	SPRB	Sale	593,000	.76	447,715
2024-03-20	SPRB	Sale	359,979	.73	264,224
2024-03-18	SPRB	Sale	842,020	.77	646,671
2024-03-14	SPRB	Sale	1,912,316	.89	1,698,136
2023-02-16	SPRB	Buy	2,208,000	3.17	6,999,360
2020-10-14	SPRB	Buy	250,000	15.00	3,750,000

Table 36. Insider trading of Flexion Therapeutics Inc (FLXN) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2015-06-18	FLXN	Sale	35,700	21.51	767,907
2015-06-19	FLXN	Sale	50,888	20.07	1,021,220
2015-06-22	FLXN	Sale	63,412	20.55	1,302,862
2014-12-17	FLXN	Buy	500,000	17.00	8,500,000
2014-02-18	FLXN	Buy	692,308	13.00	9,000,004

Table 37. Insider trading of Corvus Pharmaceuticals, Inc. (CRVS) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-07-07	CRVS	Sale	796,622	5.25	4,183,062
2020-07-08	CRVS	Sale	741,440	5.38	3,985,240
2019-07-23	CRVS	Sale	39,716	5.32	211,130
2019-07-24	CRVS	Sale	53,240	5.01	266,732
2019-07-25	CRVS	Sale	1,400,000	4.00	5,600,000
2018-03-12	CRVS	Buy	1,176,470	8.50	9,999,995
2017-06-23	CRVS	Buy	20,000	10.95	219,000
2016-03-29	CRVS	Buy	666,666	15.00	9,999,990

Table 38. Insider trading of Verve Therapeutics, Inc. (VERV) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2021-06-21	VERV	Buy	350,000	19.00	6,650,000

Table 39. Insider trading of Io Biotech, Inc. (IOBT) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2024-07-26	IOBT	Sale	23,478	1.31	30,779
2024-07-25	IOBT	Sale	51,522	1.33	68,318
2024-05-10	IOBT	Sale	658,809	1.22	802,429
2024-02-09	IOBT	Sale	658,809	1.50	988,213
2023-08-09	IOBT	Buy	2,469,135	2.02	4,999,998
2021-11-09	IOBT	Buy	325,000	14.00	4,550,000

Table 40. Insider trading of Zs Pharma, Inc. (ZSPH) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2014-06-23	ZSPH	Buy	275,000	18.00	4,950,000

Table 41. Insider trading of Mirum Pharmaceuticals, Inc. (MIRM) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2019-07-22	MIRM	Buy	575,000	15.00	8,625,000

Table 42. Insider trading of Aligos Therapeutics, Inc. (ALGS) by Novo Holdings A/s

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-10-20	ALGS	Buy	200,000	15.00	3,000,000

Insider trading activities including stock purchases, stock sales, and option exercises listed in the above table cannot be completely guaranteed as to their accuracy. For more information regarding the trades made by Novo Holdings A/s (Officer of Io Biotech, Inc. at the time of this reporting) see the Securities and Exchange Commission (SEC) website.

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