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Insider Trading History of Ra Capital Healthcare Fund Lp

The following table details the insider trading activities (stock purchases, stock sales, and stock option exercises) by Ra Capital Healthcare Fund Lp since 2010. The trader's CIK number is 1315082. At the time of the last reporting, Ra Capital Healthcare Fund Lp was the 10% Owner of Synthorx, Inc.. (stock ticker symbol THOR). Also see all insider trading activities at Synthorx, Inc..

Note that in the past RA Capital Healthcare Fund LP also reported insider trading activities as an insider of the following companies:

Yearly summary of insider trading at Wave Life Sciences Ltd. (WVE) by Ra Capital Healthcare Fund Lp

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2015	WVE	1,875,000	$30,000,000	0	$0	0	$0

Yearly summary of insider trading at Dicerna Pharmaceuticals Inc (DRNA) by Ra Capital Healthcare Fund Lp

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2017	DRNA	0	$0	0	$0	2,645,442	$0
2014	DRNA	1,000,000	$15,000,000	0	$0	0	$0

Yearly summary of insider trading at Achillion Pharmaceuticals Inc (ACHN) by Ra Capital Healthcare Fund Lp

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2014	ACHN	0	$0	10,535,000	$109,854,405	0	$0
2013	ACHN	9,913,946	$26,900,008	0	$0	0	$0

Yearly summary of insider trading at Synthorx, Inc. (THOR) by Ra Capital Healthcare Fund Lp

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2018	THOR	4,545,455	$50,000,005	0	$0	0	$0

Yearly summary of insider trading at Aclaris Therapeutics, Inc. (ACRS) by Ra Capital Healthcare Fund Lp

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	ACRS	23,440	$453,811	525,550	$12,731,097	0	$0
2015	ACRS	249,610	$3,494,680	0	$0	0	$0

Yearly summary of insider trading at Biospecifics Technologies Corp (BSTC) by Ra Capital Healthcare Fund Lp

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2010	BSTC	0	$0	215,141	$6,213,876	0	$0

Yearly summary of insider trading at Derma Sciences, Inc. (DSCI) by Ra Capital Healthcare Fund Lp

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2014	DSCI	0	$0	300,000	$3,547,500	0	$0
2013	DSCI	3,945	$44,973	0	$0	0	$0

Insider trading activities at 7 companies by Ra Capital Healthcare Fund Lp:

1. Wave Life Sciences Ltd. (WVE)

2. Dicerna Pharmaceuticals Inc (DRNA)

3. Achillion Pharmaceuticals Inc (ACHN)

4. Synthorx, Inc. (THOR)

5. Aclaris Therapeutics, Inc. (ACRS)

6. Biospecifics Technologies Corp (BSTC)

7. Derma Sciences, Inc. (DSCI)

Table 1. Insider trading of Wave Life Sciences Ltd. (WVE) by Ra Capital Healthcare Fund Lp

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2015-11-16	WVE	Buy	1,875,000	16.00	30,000,000

Table 2. Insider trading of Dicerna Pharmaceuticals Inc (DRNA) by Ra Capital Healthcare Fund Lp

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2017-12-18	DRNA	Option Ex	2,645,442	.00	0
2014-02-04	DRNA	Buy	1,000,000	15.00	15,000,000

Table 3. Insider trading of Achillion Pharmaceuticals Inc (ACHN) by Ra Capital Healthcare Fund Lp

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2014-09-29	ACHN	Sale	221,014	10.96	2,423,197
2014-09-30	ACHN	Sale	1,111,000	10.06	11,176,660
2014-09-25	ACHN	Sale	497,986	11.04	5,499,259
2014-09-26	ACHN	Sale	670,000	11.06	7,408,190
2014-09-24	ACHN	Sale	1,204,929	11.26	13,571,115
2014-09-19	ACHN	Sale	1,164,860	11.67	13,589,256
2014-09-22	ACHN	Sale	445,689	11.09	4,941,799
2014-09-23	ACHN	Sale	984,522	11.08	10,905,550
2014-08-18	ACHN	Sale	1,993,978	9.66	19,255,845
2014-08-15	ACHN	Sale	2,241,022	9.41	21,083,534
2013-11-20	ACHN	Buy	1,110,000	2.57	2,848,260
2013-10-31	ACHN	Buy	1,186,007	2.38	2,823,882
2013-10-14	ACHN	Buy	2,369,229	2.79	6,617,256
2013-10-11	ACHN	Buy	2,448,710	2.55	6,244,210
2013-09-30	ACHN	Buy	2,800,000	2.99	8,366,400

Table 4. Insider trading of Synthorx, Inc. (THOR) by Ra Capital Healthcare Fund Lp

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2018-12-11	THOR	Buy	4,545,455	11.00	50,000,005

Table 5. Insider trading of Aclaris Therapeutics, Inc. (ACRS) by Ra Capital Healthcare Fund Lp

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-09-15	ACRS	Sale	351,950	24.08	8,474,252
2016-09-16	ACRS	Sale	173,600	24.52	4,256,845
2016-01-15	ACRS	Buy	1,800	19.86	35,742
2016-01-19	ACRS	Buy	4,200	19.88	83,479
2016-01-20	ACRS	Buy	1,803	19.88	35,849
2016-01-13	ACRS	Buy	5,543	19.97	110,677
2016-01-12	ACRS	Buy	5,941	19.12	113,585
2016-01-11	ACRS	Buy	4,153	17.93	74,479
2015-10-29	ACRS	Buy	95,000	14.00	1,330,000
2015-10-28	ACRS	Buy	149,200	14.00	2,088,800
2015-10-22	ACRS	Buy	5,410	14.03	75,880

Table 6. Insider trading of Biospecifics Technologies Corp (BSTC) by Ra Capital Healthcare Fund Lp

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2010-02-26	BSTC	Sale	10,000	28.83	288,300
2010-02-23	BSTC	Sale	1,005	29.34	29,486
2010-02-22	BSTC	Sale	21,303	29.01	618,000
2010-02-17	BSTC	Sale	50,000	29.05	1,452,500
2010-02-03	BSTC	Sale	132,833	28.80	3,825,590

Table 7. Insider trading of Derma Sciences, Inc. (DSCI) by Ra Capital Healthcare Fund Lp

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2014-01-10	DSCI	Sale	300,000	11.82	3,547,500
2013-04-29	DSCI	Buy	3,945	11.40	44,973

Insider trading activities including stock purchases, stock sales, and option exercises listed in the above table cannot be completely guaranteed as to their accuracy. For more information regarding the trades made by Ra Capital Healthcare Fund Lp (10% Owner of Synthorx, Inc. at the time of this reporting) see the Securities and Exchange Commission (SEC) website.

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